Description

Arginine Vasopressin-D5 is a deuterium-labeled analog of the endogenous neurohypophysial hormone, Arginine Vasopressin (AVP). This stable isotope-labeled compound is an essential tool for quantitative bioanalytical research, providing a critical internal standard for mass spectrometry. It is primarily utilized by researchers and analytical laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors who require precise and accurate quantification of vasopressin levels in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the precise quantification of endogenous Arginine Vasopressin in biological samples (e.g., plasma, serum, urine, tissue homogenates) using Liquid Chromatography-Tandem Mass Spectrometry.
• Metabolic Pathway Studies: Used in pharmacokinetic (PK) and pharmacodynamic (PD) research to trace and study the metabolism, distribution, and clearance of vasopressin and related analogs.
• Biomarker Assay Development: Essential for developing and validating highly sensitive and specific clinical diagnostic assays aimed at measuring vasopressin for research into conditions like diabetes insipidus, SIADH (Syndrome of Inappropriate Antidiuretic Hormone Secretion), and cardiovascular disorders.
• Pharmaceutical R&D: Employed in drug discovery and development programs targeting the vasopressin receptor system, ensuring accurate measurement of drug candidates and their effects on endogenous hormone levels.
• Quality Control Reference: Acts as a certified reference material for quality control and assurance in the production of peptide-based therapeutics or diagnostic kits.

Basic Information

Product Name	Arginine Vasopressin-D5
CAS No.	1356383-11-3
Molecular Formula	C46H60D5N13O12S2
Molecular Weight	1085.3 g/mol (for unlabeled AVP: ~1084.2 g/mol)
Synonyms	AVP-d5; [d5]-Arginine Vasopressin; Deuterated Arginine Vasopressin; Argipressin-d5; 8-Arginine Vasopressin-d5; ADH-d5 (Antidiuretic Hormone-d5); Vasopressin-d5; [Phe(3,4,5-d3), Tyr(2,6-d2)]-AVP
EINECS	Contact for details

Quality Control

Our Arginine Vasopressin-D5 is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity (by MS), water content, and other critical parameters. We support research and development with materials suitable for use under GLP (Good Laboratory Practice) guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 5.0 %
Peptide Content	≥ 80%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.