Description

Ascorbic Acid 13C6 is a stable isotope-labeled analog of Vitamin C, where all six carbon atoms are the carbon-13 isotope. This compound is essential as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is critically needed by research laboratories, pharmaceutical developers, and CROs (Contract Research Organizations) for applications in drug metabolism studies (DMPK), clinical research, and advanced nutritional analysis.

Application

• Mass Spectrometry Internal Standard: Primary use as a quantitative reference standard in LC-MS and GC-MS for accurate measurement of endogenous ascorbic acid levels.
• Drug Metabolism & Pharmacokinetics (DMPK): Tracing and quantifying the absorption, distribution, metabolism, and excretion of Vitamin C and related compounds in preclinical and clinical studies.
• Clinical Research & Diagnostics: Enabling precise analysis of Vitamin C status in human plasma, serum, and tissue samples for nutritional and disease-state investigations.
• Stable Isotope Labeling Studies: Used in metabolic flux analysis and biochemical pathway tracing to understand Vitamin C biosynthesis and utilization.
• Pharmaceutical Quality Control: Ensuring the accuracy of assay methods for Vitamin C in raw materials and finished dosage forms under GMP guidelines.
• Nutritional Science Research: Investigating bioavailability, bioequivalence, and the precise role of ascorbic acid in human health and disease prevention.

Basic Information

Product Name	Ascorbic Acid 13C6
CAS No.	1354064-87-1
Molecular Formula	C6H8O6 (fully labeled with 13C)
Molecular Weight	~178.1 g/mol (exact mass depends on isotopic enrichment)
Synonyms	L-Ascorbic Acid-13C6; Vitamin C-13C6; (5R)-5-[(1S)-1,2-Dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one-13C6; 13C6 Labeled Ascorbic Acid; Stable Isotope-Labeled Vitamin C; L-3-Ketothreohexuronic acid lactone-13C6; Isotopic Internal Standard for Ascorbic Acid
EINECS	Contact for details

Quality Control

Every batch of Ascorbic Acid 13C6 is manufactured and tested to meet the stringent requirements for stable isotope-labeled reference materials. Our quality assurance includes verification of isotopic enrichment (≥99 atom % 13C) and chemical purity (≥98%) via advanced analytical techniques. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific data on isotopic purity, chemical assay, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under inert atmosphere. This product is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (13C)	≥99 atom %
Chemical Purity (HPLC)	≥98.0%
Specific Rotation	[α]20/D +20.5° to +21.5° (c=1, H2O)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.