Description

Peficitinib Hydrobromide is a high-purity, small molecule active pharmaceutical ingredient (API) with the CAS registry number 1353219-05-2. This compound is a selective Janus kinase (JAK) inhibitor of significant interest for its therapeutic potential in treating autoimmune and inflammatory disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic research institutions focused on immunology and drug discovery.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of investigational new drugs targeting JAK-mediated pathways.
• Research & Development: Critical reference standard and building block for preclinical studies in autoimmune disease models, including rheumatoid arthritis and psoriasis.
• Biochemical Research: Used as a selective tool compound to study JAK-STAT signaling mechanisms and cellular responses in immunology.
• Analytical Standard: Serves as a high-purity calibrant for method development and quality control in HPLC, LC-MS, and NMR analyses.
• Process Chemistry: Intermediate for the synthesis of related JAK inhibitor analogs and derivative compounds in medicinal chemistry programs.

Basic Information

Product Name	Peficitinib Hydrobromide
CAS No.	1353219-05-2
Molecular Formula	C25H31N7O2 • HBr
Molecular Weight	566.49 g/mol
Synonyms	ASP015K; Peficitinib HBr; (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-3-carboxamide hydrobromide; JNJ-54781532; 1H-Pyrrolo[2,3-b]pyrazine, 6-[((3S,4R)-1-(2,2,2-trifluoroethyl)-4-(hydroxymethyl)-3-pyrrolidinyl)amino]-7-cyano-, hydrobromide (1:1)
EINECS	Contact for details

Quality Control

Our Peficitinib Hydrobromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, residual solvent analysis, and identity confirmation (IR, NMR, MS) to ensure it meets stringent standards for pharmaceutical research. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Chiral Purity	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.