Description

3-Fluoro-5-(Trifluoromethoxy)Cinnamic Acid, 97% is a high-purity fluorinated cinnamic acid derivative, a crucial building block in advanced organic synthesis. This compound matters for its unique trifluoromethoxy and fluorine substituents, which are strategically placed to modulate the electronic and steric properties of target molecules, enhancing their biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly in medicinal chemistry for lead optimization.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in areas targeting CNS disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups improve lipophilicity and target binding.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated organic electronic materials, contributing to improved performance and stability in displays.
• Chemical Biology Probes: Employed in the design of molecular probes and tags for studying biological processes due to its distinctive spectroscopic signature.
• Polymer Modification: Acts as a monomer or cross-linking agent for introducing fluorinated segments into specialty polymers, enhancing chemical resistance.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs serving the global life sciences market.

Basic Information

Product Name	3-Fluoro-5-(Trifluoromethoxy)Cinnamic Acid, 97%
CAS No.	1353001-72-5
Molecular Formula	C₁₀H₆F₄O₃
Molecular Weight	250.15 g/mol
Synonyms	(E)-3-[3-Fluoro-5-(trifluoromethoxy)phenyl]acrylic acid; 3-Fluoro-5-(trifluoromethoxy)cinnamic acid; (2E)-3-[3-Fluoro-5-(trifluoromethoxy)phenyl]prop-2-enoic acid; 3-Fluoro-5-trifluoromethoxycinnamic Acid; 3-Fluoro-5-(trifluoromethoxy)benzeneacrylic acid; α,3-Fluoro-5-(trifluoromethoxy)cinnamic acid
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-(Trifluoromethoxy)Cinnamic Acid, 97% undergoes rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. Each lot is analyzed using validated methods including HPLC, NMR, and FTIR to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications are available upon request. Our quality management system supports cGMP and ISO standards for reliable sourcing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.