Description

2,4-Difluoro-3-(Hydroxymethyl)Phenylboronic Acid is a specialized bifunctional boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a boronic acid group and a hydroxymethyl substituent on a difluorinated aromatic ring, makes it a versatile intermediate for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of new active ingredients through Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced, fluorinated pesticides and herbicides, where the difluoro motif can enhance biological activity and stability.
• Material Science Research: Employed in the development of novel organic electronic materials, ligands for catalysts, and specialty polymers.
• Suzuki-Miyaura Cross-Coupling: Serves as a pivotal boronic acid coupling partner for creating biaryl and heterobiaryl structures, a cornerstone reaction in medicinal chemistry.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and sensors that leverage boronic acid-diol interactions.

Basic Information

Product Name	2,4-Difluoro-3-(Hydroxymethyl)Phenylboronic Acid
CAS No.	1352813-46-7
Molecular Formula	C7H7BF2O3
Molecular Weight	187.94 g/mol
Synonyms	(3-(Hydroxymethyl)-2,4-difluorophenyl)boronic acid; 2,4-Difluoro-3-(hydroxymethyl)benzeneboronic acid; B-[3-(Hydroxymethyl)-2,4-difluorophenyl]boronic acid; 3-(Hydroxymethyl)-2,4-difluorobenzeneboronic acid; 2,4-Difluoro-3-hydroxymethylphenylboronic Acid; 1352813-46-7; (2,4-Difluoro-3-(hydroxymethyl)phenyl)boronic acid
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-3-(Hydroxymethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistent performance for critical coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to guarantee it meets the stringent requirements for pharmaceutical R&D and scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical: 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.