Description

Methyl 2,6-Difluoro-4-Ethoxybenzoate is a high-purity fluorinated aromatic ester building block, essential for advanced organic synthesis. Its core value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine and ethoxy substituents into target structures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluoro and ethoxy motifs enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic cores in electronic chemicals for display and lighting technologies.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution to create complex, functionalized biphenyl and heterocyclic systems.
• Polymer Modification: Acts as a monomer or modifier for introducing fluorine into polymer backbones to alter thermal stability, solubility, and chemical resistance.
• Chemical Research & Development: A valuable tool for medicinal chemistry and process chemistry teams exploring structure-activity relationships (SAR).

Basic Information

Product Name	Methyl 2,6-Difluoro-4-Ethoxybenzoate
CAS No.	1351668-30-8
Molecular Formula	C10H10F2O3
Molecular Weight	216.18 g/mol
Synonyms	2,6-Difluoro-4-ethoxybenzoic acid methyl ester; Methyl 2,6-difluoro-4-ethoxybenzoate; 4-Ethoxy-2,6-difluorobenzoic acid methyl ester; Benzoic acid, 2,6-difluoro-4-ethoxy-, methyl ester; Methyl 4-ethoxy-2,6-difluorobenzoate; CAS 1351668-30-8
EINECS	Contact for details

Quality Control

Our Methyl 2,6-Difluoro-4-Ethoxybenzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chemical purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, assay, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC, Area %)	≥99.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.