Description

Vericiguat is a soluble guanylate cyclase (sGC) stimulator, representing a significant advancement in cardiovascular pharmacotherapy. This compound is specifically designed to address the unmet medical need in chronic heart failure by enhancing the nitric oxide-sGC-cyclic guanosine monophosphate (cGMP) pathway. It is a critical active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers and advanced research institutions developing next-generation treatments for heart failure with reduced ejection fraction (HFrEF).

Application

• Pharmaceutical API: Primary use as the active ingredient in finished dosage forms for the treatment of chronic heart failure.
• Clinical Research: Utilization in preclinical and clinical studies to investigate its efficacy and safety profile.
• Formulation Development: Serves as a key component in the R&D of novel drug delivery systems, such as tablets.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.
• Mechanistic Studies: Used in biochemical and pharmacological research to study the sGC signaling pathway.

Basic Information

Product Name	Vericiguat
CAS No.	1350653-20-1
Molecular Formula	C19H16FN5O3
Molecular Weight	381.36 g/mol
Synonyms	BAY 1021189; Verquvo (brand name); Methyl (4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl)carbamate; sGC Stimulator BAY 1021189
EINECS	Contact for details

Quality Control

Our Vericiguat is manufactured under strict quality management systems, ensuring it meets the high standards required for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and LC-MS. Certificates of Analysis (COA) are provided, detailing compliance with in-house specifications aligned with ICH Q3A/B guidelines. We support our partners with the documentation necessary for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.10%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.