Description

2,3,4-Trifluoro-5-Nitrobenzoyl Chloride is a highly functionalized aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine and nitro substituents, which are essential for modulating the electronic and steric properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, particularly in the development of fluorinated drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides where the trifluoro-nitrobenzoyl moiety imparts improved metabolic stability and bioavailability.
• Liquid Crystal & OLED Material Production: Acts as a building block for advanced electronic materials, where fluorine atoms enhance thermal stability and electro-optical properties.
• Polymer Chemistry: Employed as a monomer or cross-linking agent for creating specialty polymers with unique surface properties and chemical resistance.
• Peptide & Protein Modification: Useful as an acylating agent for modifying amino acids or peptides to introduce fluorinated aromatic groups for biochemical studies.
• Dye & Pigment Manufacturing: Intermediate in the synthesis of complex, high-performance fluorinated dyes and pigments.

Basic Information

Product Name	2,3,4-Trifluoro-5-Nitrobenzoyl Chloride
CAS No.	1349717-28-7
Molecular Formula	C7H2ClF3NO3
Molecular Weight	249.54 g/mol
Synonyms	5-Nitro-2,3,4-trifluorobenzoyl chloride; 2,3,4-Trifluoro-5-nitrobenzoic acid chloride; Benzoyl chloride, 2,3,4-trifluoro-5-nitro-; 2,3,4-Trifluoro-5-nitro-benzoic acid chloride; 2,3,4-Trifluoro-5-nitrobenzoylchloride; 1349717-28-7; 5-Nitro-2,3,4-trifluorobenzoic acid chloride
EINECS	Contact for details

Quality Control

Our 2,3,4-Trifluoro-5-Nitrobenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from moisture, strong bases, and alcohols.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.