Description

Acyclovir n-Ethyl-L-Valinate Hydrochloride is a chemically modified prodrug derivative of the established antiviral agent Acyclovir. This compound is specifically engineered to enhance bioavailability and optimize pharmacokinetic profiles for targeted therapeutic delivery. It is a critical advanced intermediate for pharmaceutical R&D and manufacturing, particularly in the development of next-generation antiviral therapies. Professionals in pharmaceutical synthesis and fine chemical production require this high-purity building block for creating more effective drug formulations.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel antiviral prodrugs and enhanced pharmaceutical formulations.
• Antiviral Drug Development: Used in research and development of next-generation herpes simplex virus (HSV) and varicella-zoster virus (VZV) treatments with improved delivery.
• Prodrug Synthesis: The n-ethyl-L-valinate moiety is designed for enzymatic cleavage, making it valuable for creating targeted prodrug strategies to increase oral bioavailability.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new analogs and derivatives of nucleoside antiviral agents.
• GMP Manufacturing: Supplied as a high-purity building block for cGMP-compliant production of active pharmaceutical ingredients (APIs).
• Reference Standard: Can be utilized as a chromatographic reference standard in analytical method development and quality control laboratories.

Basic Information

Product Name	Acyclovir n-Ethyl-L-Valinate Hydrochloride
CAS No.	1346617-49-9
Molecular Formula	C17H28N6O4 • HCl
Molecular Weight	424.91 g/mol
Synonyms	2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl (2S)-3-methyl-2-(pentanoylamino)butanoate hydrochloride; Acyclovir L-Valinate Ester Hydrochloride; Acyclovir n-Ethyl Valinate HCl; ACV n-Ethyl-L-Valinate Hydrochloride; L-Valine, N-ethyl-, 1-[2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl] ester, hydrochloride; Acyclovir Prodrug Intermediate; Valacyclovir Related Compound
EINECS	Contact for details

Quality Control

Our Acyclovir n-Ethyl-L-Valinate Hydrochloride is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral purity verification, and identification by IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes. The production can be aligned with ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.