Description

Acyclovir n-Methyl-L-Valinate Hydrochloride is a chemically modified prodrug derivative of the established antiviral agent acyclovir. This compound is specifically engineered to enhance bioavailability and targeted delivery, making it a critical intermediate in advanced pharmaceutical research and development. It is primarily utilized by pharmaceutical companies and research institutions focused on developing next-generation antiviral therapies and novel drug delivery systems.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel antiviral prodrugs.
• Antiviral Research: Used in preclinical and clinical research for developing enhanced formulations against herpes simplex virus (HSV) and varicella-zoster virus (VZV).
• Prodrug Development: Critical for studies aimed at improving the pharmacokinetic profile, membrane permeability, and oral absorption of acyclovir.
• API Synthesis: Employed in the controlled synthesis of active pharmaceutical ingredients (APIs) for specialized antiviral medications.
• Bioconjugation Studies: Utilized in research exploring peptide-drug conjugates and targeted delivery mechanisms.

Basic Information

Product Name	Acyclovir n-Methyl-L-Valinate Hydrochloride
CAS No.	1346617-39-7
Molecular Formula	C14H23N6O4 • HCl
Molecular Weight	382.84 g/mol (free base: 346.38)
Synonyms	2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl (2S)-3-methyl-2-(methylamino)butanoate hydrochloride; Acyclovir L-Valinate methyl ester HCl; Acyclovir N-Methylvalinate HCl; Acyclovir prodrug hydrochloride; L-Valine, N-methyl-, 1-(2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl) ester, hydrochloride
EINECS	Contact for details

Quality Control

Our Acyclovir n-Methyl-L-Valinate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Chiral Purity	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.