Description

9B-(4-Chlorophenyl)-2,3,5,9B-Tetrahydro-1H-Imidazo[2,1-A]Isoindol-5-Ol-D4 is a deuterated isotopologue of a complex heterocyclic compound, featuring a stable isotope label (D4) that is critical for advanced analytical and research applications. This deuterium-labeled compound is primarily valued for its use as an internal standard in mass spectrometry, enabling precise quantification and metabolic studies in pharmaceutical research and development. It is an essential material for scientists and manufacturers in the pharmaceutical, agrochemical, and academic research sectors who require high-purity, isotopically labeled reference standards.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference for the accurate quantification of its non-deuterated counterpart in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development: Used to validate and calibrate sensitive analytical methods, ensuring reliability and regulatory compliance in assay protocols.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants during drug substance manufacturing.
• Metabolite Identification: Facilitates the structural elucidation of drug metabolites using advanced spectroscopic techniques.
• Chemical Reference Standard: Provides a certified material for quality control laboratories to verify the identity and purity of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	9B-(4-Chlorophenyl)-2,3,5,9B-Tetrahydro-1H-Imidazo[2,1-A]Isoindol-5-Ol-D4
CAS No.	1346601-86-2
Molecular Formula	C16H11D4ClN2O
Molecular Weight	286.80 g/mol (for deuterated form)
Synonyms	9B-(4-Chlorophenyl)-2,3,5,9b-tetrahydro-1H-imidazo[2,1-a]isoindol-5-ol-d4; Deuterated 9B-(4-Chlorophenyl)-2,3,5,9b-tetrahydro-1H-imidazo[2,1-a]isoindol-5-ol; 1H-Imidazo[2,1-a]isoindol-5-ol, 9b-(4-chlorophenyl)-2,3,5,9b-tetrahydro-, d4-; (5R,9bR)-9b-(4-Chlorophenyl)-2,3,5,9b-tetrahydro-1H-imidazo[2,1-a]isoindol-5-ol-d4; Isotopically Labeled Imidazoisoindol Derivative; D4-Labeled Internal Standard 1346601-86-2
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality management systems. Each batch undergoes comprehensive analysis using advanced techniques including HPLC, NMR, and Mass Spectrometry to confirm isotopic purity, chemical purity, and identity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific data. We support compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients, ensuring the material meets the rigorous standards required for regulatory submissions and sensitive research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.