Description

Adefovir Diphosphate Triethylamine Salt is a high-purity, non-nucleoside reverse transcriptase inhibitor (NRTI) nucleotide analog intermediate. This compound is critical for pharmaceutical research and development, particularly in the synthesis of antiviral prodrugs. It is primarily utilized by research institutions and pharmaceutical manufacturers focused on developing treatments for chronic hepatitis B and other viral infections.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of Adefovir Dipivoxil and related antiviral prodrugs.
• Antiviral Research: Used in biochemical and pharmacological studies to investigate mechanisms of action against hepatitis B virus (HBV) and other DNA viruses.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical labs.
• Process Development: Employed in scaling up and optimizing manufacturing processes for nucleotide-based active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for studying nucleotide metabolism and antiviral resistance.

Basic Information

Product Name	Adefovir Diphosphate Triethylamine Salt
CAS No.	1346598-45-5
Molecular Formula	C11H23N3O8P2 • C6H15N
Molecular Weight	Contact for details
Synonyms	PMEA Diphosphate Triethylamine Salt; 9-[2-(Phosphonomethoxy)ethyl]adenine Diphosphate TEA Salt; Adefovir Diphosphate TEA Salt; GS-0393 Triethylamine Salt; Bis(POM)PMEA Intermediate Salt; [[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic Acid Diphosphate Triethylamine Salt
EINECS	Contact for details

Quality Control

Our Adefovir Diphosphate Triethylamine Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.