Description

Methyl 5-(Chloromethyl)-2-Fluorobenzoate is a high-purity fluorinated aromatic ester building block of significant importance in advanced organic synthesis. Its bifunctional structure, featuring both a reactive chloromethyl group and a fluorinated aromatic ring, makes it a versatile precursor for constructing complex molecular architectures. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorinated liquid crystals for advanced display technologies.
• Polymer Modification: Employed to introduce functional aromatic groups into polymer backbones, altering material properties like thermal stability and solubility.
• Cross-Coupling Reactions: The aromatic halide moiety makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl systems.
• Chemical Research: Utilized in academic and industrial R&D for exploring new fluorination methodologies and constructing specialty fine chemicals.

Basic Information

Product Name	Methyl 5-(Chloromethyl)-2-Fluorobenzoate
CAS No.	1338563-94-2
Molecular Formula	C9H8ClFO2
Molecular Weight	202.61 g/mol
Synonyms	2-Fluoro-5-(chloromethyl)benzoic acid methyl ester; Methyl 2-fluoro-5-(chloromethyl)benzoate; 5-(Chloromethyl)-2-fluorobenzoic Acid Methyl Ester; Benzoic acid, 5-(chloromethyl)-2-fluoro-, methyl ester; Methyl 5-chloromethyl-2-fluorobenzoate
EINECS	Contact for details

Quality Control

Every batch of Methyl 5-(Chloromethyl)-2-Fluorobenzoate is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with detailed control of related substances and residual solvents. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.