Description

(3R,8S,9S,12S) Atazanavir is a high-purity, stereochemically defined pharmaceutical intermediate and reference standard. This compound is a critical building block in the synthesis of the antiretroviral drug Atazanavir, a protease inhibitor used in HIV treatment regimens. It is essential for pharmaceutical R&D, process development, and quality control laboratories requiring a specific enantiomeric form for accurate biological activity and regulatory compliance.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: As a key chiral intermediate in the commercial production of Atazanavir sulfate.
• Research & Development: For method development, route scouting, and process optimization in antiviral drug discovery.
• Analytical Reference Standard: Used in HPLC, LC-MS, and NMR for identity confirmation, assay, and impurity profiling of bulk APIs.
• Regulatory Submissions: Serves as a characterized starting material or intermediate in Drug Master Files (DMFs) and regulatory dossiers.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.
• Academic Research: For biochemical and pharmacological studies investigating protease inhibitor mechanisms.

Basic Information

Product Name	(3R,8S,9S,12S) Atazanavir
CAS No.	1332981-14-2
Molecular Formula	C38H52N6O7
Molecular Weight	704.87 g/mol
Synonyms	Atazanavir Intermediate; (3R,8S,9S,12S)-Atazanavir; BMS-232632 Intermediate; (3R,8S,9S,12S)-N-(1-Benzyl-2-hydroxy-3-methyl-3-{[(2S)-2-[[(2S,3S)-2-hydroxy-3-[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl]amino]-1-oxo-4-phenylbutyl]amino}butyl)-5,5-dimethyl-1,3-thiazolidine-4-carboxamide; HIV-1 Protease Inhibitor Intermediate; AZV Intermediate
EINECS	Contact for details

Quality Control

Our (3R,8S,9S,12S) Atazanavir is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to support cGMP, ICH Q7, and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.