Description

L-Ascorbic Acid-13C6 is a stable isotope-labeled analog of Vitamin C, where all six carbon atoms are the carbon-13 isotope. This high-purity compound is essential for advanced analytical and research applications requiring precise metabolic tracing and quantification. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and analytical service providers for applications in mass spectrometry, NMR spectroscopy, and pharmacokinetic studies.

Application

• Internal Standard for Quantitative Analysis: Used as a certified reference material in LC-MS and GC-MS for the accurate quantification of endogenous ascorbic acid in complex biological matrices like plasma, serum, and tissue homogenates.
• Metabolic Pathway Tracing: Employed in in vitro and in vivo studies to elucidate the absorption, distribution, metabolism, and excretion (ADME) pathways of Vitamin C using isotope ratio mass spectrometry.
• Stable Isotope Dilution Assays (SIDA): Serves as the ideal spike-in standard for high-accuracy mass spectrometric methods, minimizing matrix effects and improving data reliability in clinical and nutritional research.
• Pharmaceutical Development: Critical in the development and validation of bioanalytical methods for new drug formulations containing or interacting with ascorbic acid.
• Nutritional and Biochemical Research: Facilitates studies on antioxidant mechanisms, collagen synthesis, and immune function at the molecular level with high isotopic purity.

Basic Information

Product Name	L-Ascorbic Acid-13C6
CAS No.	1331939-77-5
Molecular Formula	13C6H8O6
Molecular Weight	182.08 g/mol (for 13C6)
Synonyms	Vitamin C-13C6; (5R)-5-[(1S)-1,2-Dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one-13C6; L-Ascorbate-13C6; 3-Oxo-L-gulofuranolactone-13C6; Ascorbic Acid-13C6; Isotopic Vitamin C; [13C6]-Ascorbic Acid; 13C6-L-Ascorbic Acid
EINECS	Contact for details

Quality Control

Every batch of L-Ascorbic Acid-13C6 is manufactured and analyzed under strict quality systems to ensure exceptional isotopic and chemical purity, critical for sensitive analytical applications. Our products undergo rigorous quality testing, including NMR and MS for isotopic enrichment verification and HPLC for chemical purity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for isotopic purity, chemical assay, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) in a cool, dry place. This product is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will compromise stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Purity (13C6)	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	+20.5° to +21.5°
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.