Description

Rhein-13C6 is a stable isotope-labeled analog of Rhein, where six carbon atoms are replaced with the carbon-13 isotope. This compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and precision in analytical measurements. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, nutraceutical, and biomedical research sectors who require definitive quantification of Rhein and its metabolites.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a high-purity internal standard for the accurate quantification of Rhein in complex biological matrices such as plasma, serum, and tissue homogenates.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) for Rhein-based pharmaceutical formulations.
• Biomarker Research and Validation: Used in the development and validation of clinical assays to measure Rhein levels as a potential biomarker.
• Quality Control and Assurance: Critical for ensuring batch-to-batch consistency and verifying the active ingredient content in finished pharmaceutical products and herbal extracts containing Rhein.
• Stable Isotope Dilution Assays (SIDA): Provides the foundation for this gold-standard analytical technique, minimizing matrix effects and improving data reliability.

Basic Information

Product Name	Rhein-13C6
CAS No.	1330166-42-1
Molecular Formula	C1513C6H8O6
Molecular Weight	~290.2
Synonyms	4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid-13C6; Cassic acid-13C6; Monorhein-13C6; Rhubarb yellow-13C6; 1,8-Dihydroxy-3-carboxyanthraquinone-13C6; Rhein (13C6); [13C6]-Rhein
EINECS	Contact for details

Quality Control

Every batch of Rhein-13C6 is manufactured and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR (1H, 13C) and mass spectrometry. A detailed Certificate of Analysis (COA) specifying purity, isotopic enrichment, and solvent content is provided with each shipment to ensure compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product at 2-8°C.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Isotopic Purity (MS)	≥ 99%
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.