Description

α-Ketoisovaleric Acid-13C,D Sodium Salt is a stable, isotopically labeled sodium salt of α-ketoisovaleric acid, a key intermediate in branched-chain amino acid metabolism. This high-purity compound is essential for advanced research and development requiring precise metabolic tracing and quantification. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for applications in metabolic studies, stable isotope labeling, and as a critical reference standard.

Application

• Stable Isotope Labeling in Metabolic Research: Used as a tracer in in vitro and in vivo studies to investigate the metabolic pathways of valine and other branched-chain amino acids.
• Mass Spectrometry (MS) & Nuclear Magnetic Resonance (NMR) Standards: Serves as a critical internal standard or reference material for quantitative analysis in proteomics, metabolomics, and pharmacokinetic studies.
• Pharmaceutical Intermediate: Acts as a labeled building block in the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs) for clinical research.
• Diagnostic Reagent Development: Employed in the formulation of assays and kits for the detection and monitoring of metabolic disorders, such as Maple Syrup Urine Disease (MSUD).
• Biochemical Research: Utilized in enzymatic studies to understand the function of enzymes like branched-chain α-keto acid dehydrogenase complex (BCKDC).
• Nutritional Science Studies: Applied in research exploring amino acid metabolism, protein synthesis, and nutritional interventions.

Basic Information

Product Name	α-Ketoisovaleric Acid-13C,D Sodium Salt
CAS No.	1329835-35-9
Molecular Formula	C413CH6DO3Na
Molecular Weight	Contact for details
Synonyms	2-Oxoisovaleric-3-13C-4-d Acid Sodium Salt; Sodium 2-Ketoisovalerate-13C,d; 2-Keto-3-methylbutyric-3-13C-4-d Acid Sodium Salt; α-Ketoisovalerate-13C,d Sodium; 3-Methyl-2-oxobutyric-3-13C-4-d Acid Sodium Salt; Sodium 3-Methyl-2-oxobutanoate-13C,d; 2-Oxoisovalerate Sodium Salt-13C,d; KIV-13C,d Sodium Salt
EINECS	Contact for details

Quality Control

Our α-Ketoisovaleric Acid-13C,D Sodium Salt is manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity, meeting the rigorous demands of research and pharmaceutical development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (e.g., 13C, D), chemical purity by HPLC, and other critical parameters. We adhere to cGMP principles where applicable to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
13C Isotopic Enrichment	≥ 99 atom % 13C
Deuterium (D) Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.