Description

1'-Benzyl-1,4'-Bipiperidine-4'-Carboxamide-D10 is a deuterated analog of a key pharmaceutical intermediate, where ten hydrogen atoms are replaced with deuterium, a stable isotope. This deuteration is strategically employed to alter the pharmacokinetic and metabolic profile of active pharmaceutical ingredients, enhancing their stability and efficacy. This compound is essential for researchers and developers in pharmaceutical R&D, particularly for creating deuterated drug candidates in areas such as neurology and oncology, and for use in advanced metabolic studies and analytical method development.

Application

• Deuterated Drug Discovery & Development: Serves as a critical building block for synthesizing novel deuterium-labeled pharmaceutical compounds aimed at improving metabolic stability and extending drug half-life.
• Metabolic Pathway Tracing: Used as a stable isotope-labeled internal standard in mass spectrometry for precise quantification and mapping of metabolic pathways in preclinical studies.
• Pharmacokinetics/Pharmacodynamics (PK/PD) Research: Enables accurate and sensitive analysis of drug absorption, distribution, metabolism, and excretion (ADME) in biological systems.
• Reference Standard for Analytical Testing: Provides a high-purity certified reference material for method validation, quality control, and regulatory submissions in pharmaceutical analysis.
• Chemical Biology Probes: Utilized in the development of labeled probes for studying receptor-ligand interactions and other biochemical mechanisms.
• Isotope Effect Studies: Facilitates research into the kinetic isotope effect (KIE) to understand reaction mechanisms and optimize synthetic routes.

Basic Information

Product Name	1'-Benzyl-1,4'-Bipiperidine-4'-Carboxamide-D10
CAS No.	1329616-19-4
Molecular Formula	C18H17D10N3O
Molecular Weight	299.46 g/mol
Synonyms	1'-Benzyl-1,4'-bipiperidine-4'-carboxamide-d10; 1,4'-Bipiperidine, 1'-benzyl-4'-(aminocarbonyl)-, deuterated; Benzylbipiperidinecarboxamide-d10; Deuterated Benzyl Bipiperidine Carboxamide; 4'-(Aminocarbonyl)-1'-benzyl-1,4'-bipiperidine-d10; 1'-Benzyl-4'-carbamoyl-1,4'-bipiperidine-d10; [D10]-1'-Benzyl-1,4'-bipiperidine-4'-carboxamide
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality management systems. Each batch of 1'-Benzyl-1,4'-Bipiperidine-4'-Carboxamide-D10 undergoes rigorous analytical testing, including NMR (¹H, ²H, ¹³C) for isotopic purity and structural confirmation, and HPLC/UPLC for chemical purity assessment. We provide comprehensive Certificates of Analysis (COA) detailing assay, isotopic enrichment (D-content), and impurity profiles, ensuring compliance with research and development standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (²H NMR)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.