Description

Chlorogenic Acid-13C6 is a stable isotope-labeled analog of the naturally occurring polyphenol, chlorogenic acid, where six carbon atoms are replaced with the carbon-13 isotope. This compound is essential for use as an internal standard in quantitative mass spectrometry, enabling highly accurate and precise measurement of chlorogenic acid in complex biological and botanical matrices. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, nutraceutical, and food science industries who require definitive analytical data for method development, validation, and regulatory compliance.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a high-purity internal standard for the accurate quantification of chlorogenic acid and its metabolites in pharmacokinetic and bioavailability studies.
• Pharmaceutical Research & Development: Used in the analysis of herbal medicines and botanical drug products to ensure batch-to-batch consistency and verify active ingredient content.
• Nutraceutical & Dietary Supplement Analysis: Critical for assay validation and quality control of green coffee bean extract, artichoke extract, and other supplements containing chlorogenic acid.
• Food & Beverage Science: Enables precise measurement of chlorogenic acid in coffee, tea, fruits, and vegetables for nutritional labeling, authenticity testing, and research into antioxidant properties.
• Clinical & Biomedical Research: Facilitates metabolic pathway tracing and biomarker discovery studies related to chlorogenic acid's biological effects.
• Method Development & Validation: Provides a definitive reference for developing and validating new analytical methods in compliance with ICH, FDA, and other regulatory guidelines.

Basic Information

Product Name	Chlorogenic Acid-13C6
CAS No.	1323443-06-6
Molecular Formula	C1613C6H18O9
Molecular Weight	~372.2 g/mol (labeled)
Synonyms	3-O-Caffeoylquinic Acid-13C6; (1S,3R,4R,5R)-3-[[(2E)-3-(3,4-Dihydroxyphenyl)prop-2-enoyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylic Acid-13C6; 5-Caffeoylquinic Acid-13C6; 5-O-Caffeoylquinic Acid-13C6; Heriguard-13C6; Chlorogensäure-13C6; 13C6-labeled Chlorogenic Acid; Isochlorogenic Acid a-13C6 (related isomer)
EINECS	Contact for details

Quality Control

Our Chlorogenic Acid-13C6 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced techniques including NMR, HPLC, and high-resolution mass spectrometry to confirm identity, purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic purity, and impurity profile is provided with every shipment, supporting compliance with GMP and ISO 17025 standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99 atom % 13C
Isotopic Enrichment	≥ 99% on six labeled positions
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.