Description

Spermidine-(Butane-13C4) Trihydrochloride is a stable isotope-labeled analog of the essential polyamine spermidine, where the butane chain is uniformly labeled with carbon-13. This compound is a critical tool for quantitative mass spectrometry, enabling precise tracking and measurement of spermidine metabolism in complex biological systems. It is primarily required by researchers and analytical laboratories in the pharmaceutical, biotechnology, and life science sectors for advanced metabolomic studies, drug discovery, and biomarker validation.

Application

• Internal Standard for LC-MS/MS: Serves as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for accurate measurement of endogenous spermidine levels in biological samples (e.g., plasma, tissue, cell culture).
• Metabolic Pathway Tracing: Used in stable isotope-resolved metabolomics (SIRM) to elucidate the dynamics of polyamine biosynthesis, interconversion, and catabolism.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise quantification of drug-induced changes in spermidine metabolism during preclinical and clinical research.
• Biomarker Discovery & Validation: Facilitates the development of reliable diagnostic assays by providing a stable isotope-labeled target for normalization and quality control.
• Nutritional and Aging Research: Applied in studies investigating the role of spermidine in autophagy, longevity, and dietary interventions.
• Quality Control in Pharmaceutical Manufacturing: Used as a reference material to ensure the consistency and purity of spermidine-based active pharmaceutical ingredients (APIs) or nutraceuticals.

Basic Information

Product Name	Spermidine-(Butane-13C4) Trihydrochloride
CAS No.	1313734-84-7
Molecular Formula	C713C4H26N3 • 3HCl
Molecular Weight	Approx. 348.7 g/mol (for 13C4 labeled form)
Synonyms	N-(3-Aminopropyl)-1,4-butanediamine-(butane-13C4) trihydrochloride; [13C4]-Spermidine trihydrochloride; Spermidine-13C4 trihydrochloride; 1,5,10-Triazadecane-(butane-13C4) trihydrochloride; Isotopically labeled spermidine HCl; 13C-labeled polyamine internal standard; N-(3-Aminopropyl)-13C4-butane-1,4-diamine trihydrochloride
EINECS	Contact for details

Quality Control

Every batch of Spermidine-(Butane-13C4) Trihydrochloride is manufactured and analyzed under strict quality management systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Our products undergo rigorous quality testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with industry standards for isotopic labeled compounds. Certificates of Analysis (COA) detailing purity, isotopic purity (atom % 13C), and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Isotopic Purity (Atom % 13C)	≥ 99% on the butane-13C4 labeled position
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.