Description

Ro 25-6981 (Maleate) is a potent and selective antagonist of the NMDA receptor, specifically targeting the NR2B subunit. This high-purity compound is essential for advanced neuroscience research, enabling precise studies of glutamatergic signaling pathways and neuroplasticity. It is primarily used by pharmaceutical R&D teams and academic researchers investigating neurological disorders, pain mechanisms, and cognitive function.

Application

• Neuroscience Research: A critical tool for studying the role of NR2B-containing NMDA receptors in synaptic plasticity, learning, and memory.
• Neuropharmacology: Used in target validation and mechanistic studies for developing novel therapeutics for neurological and psychiatric conditions.
• Pain Research: Investigated for its potential role in modulating chronic pain pathways and central sensitization.
• Neuroprotection Studies: Employed in models of stroke, traumatic brain injury, and neurodegenerative diseases to understand excitotoxicity.
• Biochemical Assay Development: Serves as a reference standard in high-throughput screening and binding assays for drug discovery.
• Academic & Institutional Research: A key reagent for universities and research institutes focused on molecular and cellular neuroscience.

Basic Information

Product Name	Ro 25-6981 (Maleate)
CAS No.	1312991-76-6
Molecular Formula	C₂₁H₂₃ClN₂O₃ • C₄H₄O₄
Molecular Weight	528.96 g/mol
Synonyms	(R)-(R*,S*)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate; (αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol (Z)-2-butenedioate; Ro 25-6981; Ro25-6981; Ro256981; NMDA NR2B antagonist Ro 25-6981; 1-Piperidinepropanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-, (αR,βS)-, (2Z)-2-butenedioate (1:1)
EINECS	Contact for details

Quality Control

Our Ro 25-6981 (Maleate) is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.