Description

2-Bromo-3-(Trifluoromethoxy)Phenylboronic Acid is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. Its unique structure, featuring both bromo and trifluoromethoxy substituents, makes it a critical reagent for constructing complex molecules via cross-coupling reactions like the Suzuki-Miyaura reaction. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for creating advanced organic electronic materials, liquid crystals, and polymers with specific optoelectronic properties.
• Suzuki-Miyaura Cross-Coupling: A versatile boronic acid partner for palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl structures.
• Chemical Biology & Medicinal Chemistry: Employed in the synthesis of molecular probes, enzyme inhibitors, and tool compounds for biological target validation.
• Custom Synthesis & Contract Manufacturing: A critical raw material for custom synthesis organizations (CSOs) and CDMOs producing complex, high-value compounds for clients.

Basic Information

Product Name	2-Bromo-3-(Trifluoromethoxy)Phenylboronic Acid
CAS No.	1309980-96-8
Molecular Formula	C7H5BBrF3O3
Molecular Weight	268.83 g/mol
Synonyms	[2-Bromo-3-(trifluoromethoxy)phenyl]boronic acid; (2-Bromo-3-(trifluoromethoxy)phenyl)boronic acid; 2-Bromo-3-(trifluoromethoxy)benzeneboronic acid; Boronic acid, B-[2-bromo-3-(trifluoromethoxy)phenyl]-; 1309980-96-8; 2-Bromo-3-trifluoromethoxyphenylboronic Acid
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-(Trifluoromethoxy)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.