Description

tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)Benzylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester and a protected amine functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical companies for the synthesis of complex bioactive molecules and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Suzuki-Miyaura Cross-Coupling: The boronate ester moiety serves as a crucial coupling partner for the formation of carbon-carbon bonds with aryl halides, enabling the construction of complex biaryl structures.
• Medicinal Chemistry Research: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for potential APIs under Good Manufacturing Practice (GMP) guidelines.
• Agrochemical Synthesis: As an intermediate in the research and development of advanced crop protection agents with novel modes of action.
• Material Science: Potential precursor for the synthesis of organic electronic materials and ligands for catalysts.

Basic Information

Product Name	tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)Benzylcarbamate
CAS No.	1299483-40-1
Molecular Formula	C19H27BF3NO4
Molecular Weight	401.23 g/mol
Synonyms	Boc-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)benzylamine; N-Boc-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)benzylamine; tert-Butyl N-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)phenyl]methyl]carbamate; 4-(Boc-aminomethyl)-3-(trifluoromethyl)phenylboronic acid pinacol ester; 2-(Trifluoromethyl)-4-[[(tert-butoxycarbonyl)amino]methyl]benzeneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)Benzylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.