Description

n-[(1R,2R)-2-[[[[(8α,9S)-6'-Methoxycinchonan-9-Yl]Amino]Thioxomethyl]Amino]-1,2-Diphenylethyl]-3,5-Bis(Trifluoromethyl)-Benzenesulfonamide is a sophisticated chiral sulfonamide derivative, engineered for high selectivity and reactivity in advanced synthetic processes. Its complex molecular architecture, featuring a cinchona alkaloid core and a bis(trifluoromethyl)phenylsulfonamide group, makes it a critical component for the development of novel pharmaceuticals and fine chemicals. This compound is essential for research and manufacturing in asymmetric catalysis and as a key chiral intermediate or ligand in organic synthesis.

Application

• Asymmetric Synthesis Catalyst/Ligand: Employed as a chiral ligand or organocatalyst in enantioselective C-C and C-X bond-forming reactions.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• Chiral Resolution Agent: Used in the separation and purification of enantiomers for analytical and preparative-scale applications.
• Medicinal Chemistry Research: A valuable tool for drug discovery programs targeting receptors and enzymes where stereochemistry is crucial for activity.
• Fine Chemical Synthesis: Applied in the production of specialty chemicals, agrochemicals, and advanced materials where precise stereocontrol is required.
• Academic & Industrial R&D: Used in methodological development for new catalytic systems and synthetic transformations.

Basic Information

Item	Details
Product Name	n-[(1R,2R)-2-[[[[(8α,9S)-6'-Methoxycinchonan-9-Yl]Amino]Thioxomethyl]Amino]-1,2-Diphenylethyl]-3,5-Bis(Trifluoromethyl)-Benzenesulfonamide
CAS No.	1296152-93-6
Molecular Formula	C44H40F6N4O3S2
Molecular Weight	850.94 g/mol
Synonyms	(1R,2R)-N-[2-[[[(8α,9S)-6'-Methoxycinchonan-9-yl]carbamothioyl]amino]-1,2-diphenylethyl]-3,5-bis(trifluoromethyl)benzenesulfonamide; Cinchona Alkaloid-Derived Sulfonamide; Chiral Thiourea-Sulfonamide Hybrid Ligand; Asymmetric Organocatalyst; (R,R)-TS-Cinchona Catalyst Derivative; 1296152-93-6; 3,5-Bis(trifluoromethyl)-N-[(1R,2R)-2-({[(8α,9S)-6'-methoxycinchonan-9-yl]carbamothioyl}amino)-1,2-diphenylethyl]benzenesulfonamide
EINECS	Contact for details

Quality Control

Our production of this advanced chiral compound adheres to stringent quality protocols. Every batch undergoes comprehensive analytical characterization, including HPLC for purity and chiral assay, NMR for structural confirmation, and mass spectrometry. We ensure compliance with relevant research and development standards. A detailed Certificate of Analysis (COA), documenting identity, purity, and enantiomeric excess, is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.