Description

(3R,8S,9S,12R)-Atazanavir CAS NO 1292296-11-7 is a high-purity stereoisomer of the antiretroviral drug atazanavir, a key component in HIV protease inhibitor therapies. This specific enantiomer is critical for ensuring the intended pharmacological activity and minimizing off-target effects in advanced pharmaceutical formulations. It is an essential building block for research institutions and pharmaceutical manufacturers developing and producing next-generation HIV treatments. The compound's defined stereochemistry is paramount for achieving consistent efficacy and meeting stringent regulatory requirements for active pharmaceutical ingredients (APIs).

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a chiral intermediate in the commercial production of Atazanavir sulfate, a first-line HIV-1 protease inhibitor.
• Pharmaceutical Research & Development: Serves as a critical reference standard and starting material for developing novel protease inhibitors and studying structure-activity relationships (SAR).
• Process Chemistry & Scale-Up: Used in optimizing synthetic routes and scaling up manufacturing processes for antiretroviral drugs under cGMP conditions.
• Analytical Method Development: Employed as a high-purity standard for validating HPLC, LC-MS, and other analytical methods in quality control laboratories.
• Formulation Studies: Utilized in pre-formulation and stability testing to develop robust final dosage forms like capsules and tablets.
• Regulatory Submissions: Provides the necessary characterized material for inclusion in Drug Master Files (DMFs) and regulatory dossiers for FDA, EMA, and other health authority approvals.

Basic Information

Product Name	(3R,8S,9S,12R)-Atazanavir
CAS No.	1292296-11-7
Molecular Formula	C38H52N6O7
Molecular Weight	704.86 g/mol
Synonyms	(3R,8S,9S,12R)-Atazanavir; Atazanavir Intermediate; BMS-232632 Intermediate; (R)-Atazanavir; HIV Protease Inhibitor Intermediate; (3R,8S,9S,12R)-Methyl N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamate; (3R,8S,9S,12R)-1-Benzyl-2-hydroxy-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]propylcarbamate Methyl Ester
EINECS	Contact for details

Quality Control

Our (3R,8S,9S,12R)-Atazanavir is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR for structural confirmation, and stringent control of related substances and residual solvents. Certificates of Analysis (COA) detailing purity, identity, and all critical parameters are provided with every shipment to ensure compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.