Description

(R)-1-(2,6-Dichloro-Benzyl)-Pyrrolidin-3-Ol CAS NO 1289585-43-8 is a high-purity chiral intermediate characterized by its pyrrolidine scaffold and dichlorobenzyl substituent. This compound is of significant commercial importance as a key building block in the synthesis of advanced pharmaceutical active ingredients, particularly those targeting the central nervous system. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and production of novel drug candidates, especially in neurology and psychiatry.
• Asymmetric Synthesis: Used as a precursor or ligand in catalytic asymmetric reactions to induce chirality in target molecules.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Development: Integral in the synthetic route for potential APIs requiring a specific (R)-enantiomer configuration.
• Chemical Reference Standard: Employed as an analytical standard for quality control and method development in regulatory submissions.
• Fine Chemical Synthesis: Utilized in the multi-step synthesis of complex, high-value specialty chemicals beyond pharmaceuticals.

Basic Information

Product Name	(R)-1-(2,6-Dichloro-Benzyl)-Pyrrolidin-3-Ol
CAS No.	1289585-43-8
Molecular Formula	C11H13Cl2NO
Molecular Weight	246.13 g/mol
Synonyms	(R)-1-[(2,6-Dichlorophenyl)methyl]-3-pyrrolidinol; (3R)-1-[(2,6-Dichlorophenyl)methyl]pyrrolidin-3-ol; (R)-1-(2,6-Dichlorobenzyl)-3-hydroxypyrrolidine; (R)-1-(2,6-Dichlorobenzyl)pyrrolidin-3-ol; (R)-1-(2,6-Dichlorobenzyl)-3-pyrrolidinol; (R)-1-(2,6-Dichlorobenzyl)-3-hydroxy-pyrrolidine; (R)-1-(2,6-Dichloro-benzyl)-pyrrolidin-3-ol; 1289585-43-8
EINECS	Contact for details

Quality Control

Our (R)-1-(2,6-Dichloro-Benzyl)-Pyrrolidin-3-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.