Description

2-Formyl-6-(Trifluoromethyl)Benzoic Acid is a high-value, multi-functional aromatic building block containing both a formyl and a carboxylic acid group, ortho-substituted with a trifluoromethyl moiety. This unique structure makes it a critical intermediate for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine atoms is a key strategy for modulating bioactivity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in fine chemical synthesis for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in kinase inhibitors, anti-inflammatory agents, and CNS-targeted therapies.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers for specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Useful for constructing fluorescent tags or affinity probes due to its reactive aldehyde and acid functionalities.
• Custom Synthesis & Contract Manufacturing: A vital starting material for CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	2-Formyl-6-(Trifluoromethyl)Benzoic Acid
CAS No.	1289156-92-8
Molecular Formula	C9H5F3O3
Molecular Weight	218.13 g/mol
Synonyms	6-(Trifluoromethyl)phthalaldehyde-3-carboxylic acid; 2-Formyl-6-(trifluoromethyl)benzoic acid; 6-Trifluoromethyl-2-formylbenzoic acid; Benzoic acid, 2-formyl-6-(trifluoromethyl)-; 2-Carboxy-3-(trifluoromethyl)benzaldehyde; 3-Formyl-2-(trifluoromethyl)benzoic acid (possible numbering isomer); TFMB-aldehyde-acid
EINECS	Contact for details

Quality Control

Every batch of 2-Formyl-6-(Trifluoromethyl)Benzoic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the exacting standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (HPLC), identity (NMR, IR), and impurity profile. Our quality commitment supports compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent oxidation and hydrolysis. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.