Description

(S)-2-Hydroxy-2’-[(R)-Hydroxy(Phenyl)Methyl]-[1,1’-Binaphthalene] is a highly valuable, enantiomerically pure chiral ligand and building block derived from the BINOL (1,1'-Bi-2-naphthol) scaffold. Its precise stereochemistry makes it a critical component for inducing asymmetry in catalytic reactions, enabling the synthesis of single-enantiomer compounds with high optical purity. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require sophisticated chiral auxiliaries for asymmetric synthesis and catalysis.

Application

• Asymmetric Catalysis: Serves as a privileged chiral ligand or precursor for metal-catalyzed asymmetric reactions, including hydrogenation, alkylation, and Diels-Alder cycloadditions.
• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) where specific stereochemistry is required for biological activity.
• Chiral Resolution Agent: Used in the development of chiral stationary phases for HPLC or as a resolving agent for racemic mixtures.
• Material Science Research: Employed in the synthesis of chiral polymers, liquid crystals, or molecular devices with specific optical properties.
• Agrochemical Synthesis: Facilitates the production of enantiomerically pure herbicides, fungicides, and pesticides for enhanced efficacy and environmental safety.
• Academic & Process R&D: A vital tool for chemists in university and industrial R&D labs exploring new asymmetric methodologies and optimizing synthetic routes.

Basic Information

Item	Details
Product Name	(S)-2-Hydroxy-2’-[(R)-Hydroxy(Phenyl)Methyl]-[1,1’-Binaphthalene]
CAS No.	1281985-73-6
Molecular Formula	C27H20O2
Molecular Weight	376.45 g/mol
Synonyms	(S)-2-[(R)-Hydroxy(phenyl)methyl]-2'-hydroxy-1,1'-binaphthalene; (S)-2-[(R)-Phenyl(hydroxy)methyl]-2'-hydroxy-1,1'-binaphthyl; Chiral BINOL Derivative; Axially Chiral Diol; Asymmetric Catalyst Ligand; Enantiopure BINOL Analog; (S,R)-NOBIN-Hydroxy Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced chiral chemical adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric excess (ee). Every lot is characterized by advanced analytical techniques, including Chiral HPLC and NMR spectroscopy, to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.