Description

(3R)-5-(Trifluoromethyl)-2,3-Dihydrobenzo[B]Furan-3-Ylamine is a chiral, non-racemic amine derivative of a dihydrobenzofuran scaffold, distinguished by the presence of a trifluoromethyl group. This compound serves as a critical, high-value building block in modern pharmaceutical and agrochemical research, enabling the synthesis of novel active ingredients with enhanced metabolic stability and bioavailability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the construction of complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of central nervous system (CNS) drugs, antiviral agents, and enzyme inhibitors.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands in asymmetric catalysis, crucial for producing enantiomerically pure compounds.
• Material Science: Potential building block for specialty polymers and liquid crystals due to its rigid benzofuran core and fluorine content.
• Chemical Biology: Employed in the design of molecular probes and activity-based protein profiling (ABPP) reagents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of APIs (Active Pharmaceutical Ingredients) under cGMP conditions.

Basic Information

Product Name	(3R)-5-(Trifluoromethyl)-2,3-Dihydrobenzo[B]Furan-3-Ylamine
CAS No.	1272731-64-2
Molecular Formula	C9H8F3NO
Molecular Weight	203.16 g/mol
Synonyms	(3R)-5-(Trifluoromethyl)-2,3-dihydro-1-benzofuran-3-amine; (R)-5-(Trifluoromethyl)-2,3-dihydrobenzofuran-3-amine; (3R)-3-Amino-5-(trifluoromethyl)-2,3-dihydrobenzofuran; 5-(Trifluoromethyl)-2,3-dihydrobenzofuran-3-amine (R)-; (R)-3-Amino-5-(trifluoromethyl)-2,3-dihydrobenzofuran; (R)-5-(Trifluoromethyl)-2,3-dihydro-1-benzofuran-3-amine; 1272731-64-2; (R)-5-(Trifluoromethyl)dihydrobenzofuranylamine
EINECS	Contact for details

Quality Control

Our (3R)-5-(Trifluoromethyl)-2,3-Dihydrobenzo[B]Furan-3-Ylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC/GC), chiral excess, and impurity profile is provided with every shipment. We support development from milligram to kilogram scale with consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.