Description

1-Amino-4-Fluoro-2,3-Dihydro-1H-Indene-1-Carboxylic Acid is a high-purity, fluorinated indane derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring both an amino and a carboxylic acid functional group on a fluorinated indane scaffold, makes it invaluable for constructing complex molecular architectures with precise stereochemistry. This compound is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated pesticides and herbicides where the fluorine atom enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for designing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetic Research: The indane scaffold is utilized to create conformationally restricted peptide analogs for biochemical studies.
• Material Science Precursor: Acts as a building block for specialty polymers and advanced organic materials requiring fluorinated components.
• Chemical Biology Probes: Employed in the synthesis of fluorescent or bioactive probes for studying enzyme mechanisms and cellular processes.

Basic Information

Product Name	1-Amino-4-Fluoro-2,3-Dihydro-1H-Indene-1-Carboxylic Acid
CAS No.	1270435-39-6
Molecular Formula	C10H10FNO2
Molecular Weight	195.19 g/mol
Synonyms	1-Amino-4-fluoroindane-1-carboxylic acid; 4-Fluoro-1-aminoindane-1-carboxylic acid; 1-Carboxy-4-fluoro-2,3-dihydro-1H-inden-1-amine; 4-Fluoro-1-amino-2,3-dihydro-1H-indene-1-carboxylic acid; (1-Amino-4-fluoro-2,3-dihydro-1H-inden-1-yl)methanoic acid; 1270435-39-6; 1H-Indene-1-carboxylic acid, 1-amino-4-fluoro-2,3-dihydro-
EINECS	Contact for details

Quality Control

Our 1-Amino-4-Fluoro-2,3-Dihydro-1H-Indene-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.