Description

2-{1-[(tert-Butoxy)Carbonyl]Azepan-4-Yl}Acetic Acid is a high-purity, protected amino acid derivative featuring a seven-membered azepane ring and a tert-butoxycarbonyl (Boc) protecting group. This compound is a critical pharmaceutical intermediate and building block for medicinal chemistry research, enabling the synthesis of complex molecules with specific conformational properties. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and GPCRs.
• Peptidomimetics & Macrocyclic Compounds: Used to construct constrained peptide analogs and macrocyclic structures due to its azepane scaffold, which can improve metabolic stability and bioavailability.
• Medicinal Chemistry Research: Serves as a versatile synthon for structure-activity relationship (SAR) studies and library synthesis in early-stage drug discovery.
• Agrochemical Active Ingredient Development: Employed in the research and synthesis of new crop protection agents and herbicides.
• Chemical Biology Probes: Utilized in the development of tool compounds and probes for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the cGMP or non-GMP production of APIs and advanced intermediates.

Basic Information

Product Name	2-{1-[(tert-Butoxy)Carbonyl]Azepan-4-Yl}Acetic Acid
CAS No.	1268521-78-3
Molecular Formula	C14H25NO4
Molecular Weight	271.35 g/mol
Synonyms	2-(1-Boc-azepan-4-yl)acetic acid; 2-[1-[(2-Methylpropan-2-yl)oxycarbonyl]azepan-4-yl]acetic acid; 4-Carboxymethyl-1-N-Boc-azepane; 1-Boc-4-(carboxymethyl)azepane; 1-(tert-Butoxycarbonyl)-4-(carboxymethyl)azepane; Azepane-4-acetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-; BOC-AZE(4-CH2COOH)-OH; (1-Boc-azepan-4-yl)-acetic acid
EINECS	Contact for details

Quality Control

Our 2-{1-[(tert-Butoxy)Carbonyl]Azepan-4-Yl}Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.