Description

2'-Deoxy-3',5'-Di-o-Benzoyl-2',2'-Difluorocytidine-13C,15N2 is a stable-isotope labeled nucleoside derivative, specifically designed as a critical intermediate in the synthesis of labeled antiviral and anticancer pharmaceuticals. This compound is essential for enabling advanced pharmacokinetic and metabolic studies through mass spectrometry, providing unparalleled traceability and accuracy in drug development research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) for nucleoside analog drugs.

Application

• Isotope-Labeled API Synthesis: A key building block for the production of carbon-13 and nitrogen-15 labeled versions of antiviral drugs like gemcitabine and related cytidine analogs.
• Mass Spectrometry Internal Standards: Serves as a high-purity reference standard for quantitative bioanalysis (LC-MS/MS) in clinical trials and drug metabolism studies.
• Mechanistic & Metabolic Pathway Research: Enables tracing of drug incorporation and metabolic fate within biological systems for advanced pharmacological research.
• Process Chemistry Development: Used in route scouting and optimization for the scalable synthesis of fluorinated nucleoside therapeutics.
• Regulatory & Quality Control: Acts as a certified reference material for method validation and ensuring batch-to-batch consistency in GMP manufacturing.

Basic Information

Product Name	2'-Deoxy-3',5'-Di-o-Benzoyl-2',2'-Difluorocytidine-13C,15N2
CAS No.	1267650-42-9
Molecular Formula	C19H1513C F2N215N O5
Molecular Weight	Contact for details
Synonyms	2',2'-Difluorocytidine-13C,15N2 3',5'-Dibenzoate; 2'-Deoxy-2',2'-difluorocytidine-13C,15N2 3',5'-dibenzoate; Dibenzoate-protected 2'-deoxy-2',2'-difluorocytidine-13C,15N2; Gemcitabine intermediate-13C,15N2; 1-(3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-D-erythro-pentofuranosyl)-13C,15N2-cytosine; Labeled 2'-Deoxy-2',2'-difluorocytidine 3',5'-dibenzoate; [13C,15N2]-2'-Deoxy-3',5'-Di-o-benzoyl-2',2'-difluorocytidine
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-3',5'-Di-o-Benzoyl-2',2'-Difluorocytidine-13C,15N2 is manufactured under strict quality systems to ensure the high isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (by NMR or MS), chemical purity (by HPLC), and identity confirmation. We adhere to relevant guidelines for the production of labeled compounds for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 99 atom % 13C; ≥ 98 atom % 15N
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.