Description

3-Cyano-3-(4-Fluoro-Phenyl)-Propionic Acid is a versatile fluorinated cyano acid building block of significant importance in modern synthetic chemistry. Its molecular structure, featuring both a cyano and a carboxylic acid group on a fluorinated aromatic backbone, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors. It enables the synthesis of novel active ingredients, particularly in the development of targeted therapies and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance in display and lighting technologies.
• Peptidomimetics & Bio-conjugation: The carboxylic acid and cyano groups facilitate its use in creating peptide analogs and for bio-conjugation applications in drug delivery systems.
• Organic Synthesis & Catalysis Research: Employed in academic and industrial R&D for exploring new asymmetric synthesis routes and as a ligand precursor in catalytic systems.
• Fluorine-Containing Polymer Modifier: Can be incorporated to modify polymer properties, imparting characteristics like chemical resistance or altered surface energy.

Basic Information

Product Name	3-Cyano-3-(4-Fluoro-Phenyl)-Propionic Acid
CAS No.	1267271-26-0
Molecular Formula	C10H8FNO2
Molecular Weight	193.17 g/mol
Synonyms	3-(4-Fluorophenyl)-3-cyanopropanoic Acid; 4-Fluoro-β-cyanohydrocinnamic Acid; β-Cyano-β-(4-fluorophenyl)propionic Acid; 3-Cyano-3-(p-fluorophenyl)propanoic Acid; (4-Fluorophenyl)cyanoacetic acid, 3-oxo-; 1267271-26-0; 3-(4-Fluorophenyl)-3-oxopropanenitrile (related oxo-form)
EINECS	Contact for details

Quality Control

Our production of 3-Cyano-3-(4-Fluoro-Phenyl)-Propionic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assay, NMR and IR for structural confirmation, and KF titration for moisture content. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request, supporting compliance in GMP-aligned synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.