Description

2,4-Difluoro-5-Methylbenzoyl Chloride is a high-purity, reactive aromatic acid chloride derivative. This compound serves as a critical building block in advanced organic synthesis, enabling the efficient introduction of a substituted benzoyl moiety. It is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a difluoromethylbenzoyl scaffold.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Material Production: Serves as a building block for advanced electronic materials and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Employed as a monomer or modifying agent in the production of specialty polymers and high-performance resins.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D in medicinal chemistry and material science.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules and complex intermediates.

Basic Information

Product Name	2,4-Difluoro-5-Methylbenzoyl Chloride
CAS No.	1263376-87-9
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	5-Methyl-2,4-difluorobenzoyl chloride; 2,4-Difluoro-5-methyl-benzoic acid chloride; 2,4-Difluoro-α,α,α-trifluoro-m-toluoyl chloride (related); 5-Methyl-2,4-difluorobenzoic acid chloride; Benzoyl chloride, 2,4-difluoro-5-methyl-; m-Toluoyl chloride, 2,4-difluoro- (alternative naming)
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-5-Methylbenzoyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. Our quality management system is designed to meet the stringent requirements of cGMP and ISO standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.