Description

n-[(8α,9S)-10,11-Dihydrocinchonan-9-Yl]-2-(Diphenylphosphino)-Benzamide CAS NO 1263322-13-9 is a sophisticated chiral ligand derived from cinchona alkaloid chemistry, designed for high-performance asymmetric catalysis. This compound matters because it enables precise stereochemical control in critical synthetic transformations, directly impacting the efficiency and purity of advanced chemical manufacturing. It is essential for R&D chemists and process engineers in the pharmaceutical and fine chemical industries who require reliable, high-selectivity catalysts for producing enantiomerically pure intermediates and active pharmaceutical ingredients (APIs).

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, crucial for synthesizing chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Used in the production of enantiomerically pure building blocks for APIs, where stereochemical integrity is non-negotiable.
• Fine Chemical Manufacturing: Facilitates asymmetric C-C and C-X bond-forming reactions for high-value specialty chemicals.
• Catalyst Development & Screening: Serves as a benchmark or component in catalyst libraries for discovering new asymmetric transformations.
• Academic & Industrial R&D: A valuable tool for methodological development in synthetic organic chemistry and process optimization.

Basic Information

Product Name	n-[(8α,9S)-10,11-Dihydrocinchonan-9-Yl]-2-(Diphenylphosphino)-Benzamide
CAS No.	1263322-13-9
Molecular Formula	C₃₉H₃₇N₂OP
Molecular Weight	592.70 g/mol
Synonyms	(8α,9S)-10,11-Dihydro-N-[2-(diphenylphosphino)benzoyl]cinchonan-9-amine; (8α,9S)-N-[2-(Diphenylphosphanyl)benzoyl]-10,11-dihydrocinchonan-9-amine; Dihydrocinchona-Based P,N-Ligand; Cinchona Alkaloid-Derived Phosphino-Benzamide Ligand; Asymmetric Hydrogenation Ligand (Dihydro Series); (9S)-N-[2-(Diphenylphosphino)benzoyl]-10,11-dihydrocinchonan-9-amine; Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Our production of n-[(8α,9S)-10,11-Dihydrocinchonan-9-Yl]-2-(Diphenylphosphino)-Benzamide adheres to stringent quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized by advanced analytical techniques including HPLC, 1H/31P/13C NMR, and elemental analysis to confirm identity, purity, and the absence of metallic residues. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting cGMP-compliant development and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light may degrade its catalytic activity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.