Description

n-(9R)-Cinchonan-9-Yl-2-(Diphenylphosphino)-Benzamide is a specialized chiral ligand derived from cinchona alkaloids, designed for high-performance asymmetric catalysis. Its core value lies in enabling precise stereochemical control in critical bond-forming reactions, which is essential for producing enantiomerically pure intermediates. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for synthesizing active pharmaceutical ingredients (APIs) and advanced chiral molecules.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically enriched amino acids and amines.
• Catalyst component in transition metal-catalyzed cross-coupling and C-H activation reactions requiring stereoselectivity.
• Key reagent for the development of pharmaceutical intermediates, particularly in routes to chiral drugs targeting CNS, cardiovascular, and metabolic diseases.
• Use in academic and industrial research for exploring new methodologies in organometallic chemistry and catalysis.
• Potential application in the synthesis of agrochemicals and flavors & fragrances where chiral purity is critical.

Basic Information

Product Name	n-(9R)-Cinchonan-9-Yl-2-(Diphenylphosphino)-Benzamide
CAS No.	1263322-11-7
Molecular Formula	C39H35N2OP
Molecular Weight	578.68 g/mol
Synonyms	(9R)-Cinchonan-9-yl-2-(diphenylphosphino)benzamide; (R)-2-(Diphenylphosphino)-N-((R)-1-(6-methoxyquinolin-4-yl)ethyl)benzamide; (R)-N-((R)-1-(6-Methoxyquinolin-4-yl)ethyl)-2-(diphenylphosphino)benzamide; Cinchona Alkaloid-Derived Phosphine Ligand; (R,R)-Quinaphos; (R,R)-2-(Diphenylphosphino)-N-(1-(6-methoxyquinolin-4-yl)ethyl)benzamide; (R,R)-N-(1-(6-Methoxyquinolin-4-yl)ethyl)-2-(diphenylphosphino)benzamide; Ligand 1263322-11-7
EINECS	Contact for details

Quality Control

Our production of n-(9R)-Cinchonan-9-Yl-2-(Diphenylphosphino)-Benzamide adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment, supporting compliance in cGMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.