Description

Xanthine-13C15N2 is a stable isotope-labeled analog of xanthine, a key purine base metabolite, where specific carbon and nitrogen atoms are replaced with their stable isotopes. This compound is essential for precise quantitative analysis in mass spectrometry-based studies, providing unmatched accuracy as an internal standard. It is primarily required by researchers and quality control laboratories in the pharmaceutical, clinical diagnostics, and metabolomics fields for pharmacokinetic studies, metabolic pathway tracing, and biomarker validation.

Application

• Internal Standard for LC-MS/MS: Used for the accurate quantification of xanthine and related purine metabolites in biological matrices like plasma, urine, and tissue homogenates.
• Metabolomics Research: Enables precise tracing of purine metabolism and energy pathways in cellular and in vivo studies.
• Pharmaceutical Development: Critical for drug metabolism and pharmacokinetic (DMPK) studies of purine-based therapeutics.
• Clinical Diagnostics: Supports the development and validation of assays for disorders of purine metabolism, such as xanthinuria.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as a high-purity spike for definitive method development and reference material characterization.
• Nutritional and Sports Science: Facilitates research into purine turnover and energy metabolism under various physiological conditions.

Basic Information

Product Name	Xanthine-13C15N2
CAS No.	1262670-81-4
Molecular Formula	C513C15N2H4N2O2
Molecular Weight	154.06 g/mol (labeled)
Synonyms	1H-Purine-2,6-dione-13C15N2; 3,7-Dihydropurine-2,6-dione-13C15N2; [13C,15N2]-Xanthine; Xanthine (13C,15N2 labeled); Isotopically Labeled Xanthine; Stable Isotope-Labeled Xanthine; Xanthine-13C,15N2; Xanthine-13C,15N2 (1,3-15N2; 2-13C)
EINECS	Contact for details

Quality Control

Every batch of Xanthine-13C15N2 is manufactured and analyzed under strict quality management systems to ensure the highest isotopic and chemical purity for research applications. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical methods are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 99 atom % 15N
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.