Description

4-[(Trifluoromethoxy)Methyl]Benzoic Acid is a high-value fluorinated aromatic building block characterized by its benzoic acid core functionalized with a trifluoromethoxymethyl group. This unique structure imparts enhanced lipophilicity and metabolic stability, making it a critical intermediate for advanced material and pharmaceutical research. It is primarily sought by R&D chemists and process development scientists in the agrochemical and pharmaceutical industries for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring fluorinated motifs for improved bioavailability and target binding.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes (OLEDs) due to its influence on dielectric and photophysical properties.
• Polymer Modification: Incorporated as a monomer or additive to create specialty polymers with tailored surface energy, chemical resistance, and optical characteristics.
• Chemical Research & Development: A versatile building block in medicinal and synthetic chemistry for exploring structure-activity relationships (SAR) and creating compound libraries.

Basic Information

Product Name	4-[(Trifluoromethoxy)Methyl]Benzoic Acid
CAS No.	1262413-29-5
Molecular Formula	C9H7F3O3
Molecular Weight	220.14 g/mol
Synonyms	4-(Trifluoromethoxymethyl)benzoic acid; Benzoic acid, 4-[(trifluoromethoxy)methyl]-; α,α,α-Trifluoro-p-(methoxymethyl)benzoic Acid; 4-(Trifluoromethylmethoxy)benzoic Acid; p-[(Trifluoromethoxy)methyl]benzoic acid; 4-Carboxybenzyl trifluoromethyl ether; (4-Carboxyphenyl)methyl trifluoromethyl ether
EINECS	Contact for details

Quality Control

Our production of 4-[(Trifluoromethoxy)Methyl]Benzoic Acid adheres to stringent in-process controls and final batch release testing to ensure consistent purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and physical characteristics. Our quality system is designed to support cGMP and ISO standards for reliable supply into regulated research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.