Description

3',5-Difluoro-4'-Methyl-[1,1'-Biphenyl]-3-Carboxylic Acid is a high-purity fluorinated biphenyl carboxylic acid derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate) and versatile building block in organic synthesis. Its value lies in the precise molecular architecture that enables the construction of complex molecules, particularly for active pharmaceutical ingredients (APIs) in life sciences research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and scale-up.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, leveraging the fluorine atoms for enhanced bioactivity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), where its structure contributes to desired electronic and alignment properties.
• Organic Synthesis Building Block: Employed in Suzuki-Miyaura and other cross-coupling reactions to introduce the difluoromethyl biphenyl moiety into more complex molecular frameworks.
• Chemical Research & Development: Utilized in academic and industrial R&D settings for exploring new chemical entities and reaction pathways in medicinal and synthetic chemistry.

Basic Information

Product Name	3',5-Difluoro-4'-Methyl-[1,1'-Biphenyl]-3-Carboxylic Acid
CAS No.	1261987-60-3
Molecular Formula	C14H10F2O2
Molecular Weight	248.23 g/mol
Synonyms	[1,1'-Biphenyl]-3-carboxylic acid, 3',5-difluoro-4'-methyl-; 3-(3,5-Difluoro-4-methylphenyl)benzoic acid; 3',5-Difluoro-4'-methylbiphenyl-3-carboxylic acid; 4'-Methyl-3',5-difluorobiphenyl-3-carboxylic acid; 3-Carboxy-3',5-difluoro-4'-methylbiphenyl
EINECS	Contact for details

Quality Control

Our 3',5-Difluoro-4'-Methyl-[1,1'-Biphenyl]-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.