Description

3'-Fluoro-2-Methyl-[1,1'-Biphenyl]-4,4'-Dicarboxylic Acid is a high-purity, functionalized biphenyl dicarboxylic acid derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in the precise molecular architecture that combines a fluorine substituent and methyl group on one phenyl ring with carboxylic acid groups on the other, enabling fine-tuning of electronic and steric properties in target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and advanced materials sectors, particularly for developing active pharmaceutical ingredients (APIs) and sophisticated organic electronic materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Liquid Crystal & OLED Materials: Serves as a core precursor for the development of fluorinated biphenyl-based liquid crystals and organic light-emitting diode (OLED) materials, where the fluorine atom enhances stability and electronic performance.
• Polymer & Resin Modifier: Used to synthesize specialized polyamides, polyesters, or epoxy resins, imparting improved thermal stability, chemical resistance, and specific optical properties to high-performance polymers.
• Metal-Organic Framework (MOF) Synthesis: Acts as a versatile organic linker for constructing porous MOF materials with potential applications in gas storage, separation, and catalysis.
• Agrochemical Synthesis: Employed as an intermediate in the research and development of new-generation herbicides and fungicides with enhanced efficacy and environmental profiles.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D focused on exploring structure-activity relationships and developing new synthetic methodologies.

Basic Information

Product Name	3'-Fluoro-2-Methyl-[1,1'-Biphenyl]-4,4'-Dicarboxylic Acid
CAS No.	1261964-10-6
Molecular Formula	C15H11FO4
Molecular Weight	274.25 g/mol
Synonyms	[1,1'-Biphenyl]-4,4'-dicarboxylic acid, 3'-fluoro-2-methyl-; 3'-Fluoro-2-methylbiphenyl-4,4'-dicarboxylic acid; 2-Methyl-3'-fluorobiphenyl-4,4'-dicarboxylic acid; 4,4'-Biphenyldicarboxylic acid, 3'-fluoro-2-methyl- derivative; 3-Fluoro-2'-methyl-[1,1'-biphenyl]-4,4'-dicarboxylic acid (isomer); FMDCA (abbreviation); CAS 1261964-10-6
EINECS	Contact for details

Quality Control

Our production of 3'-Fluoro-2-Methyl-[1,1'-Biphenyl]-4,4'-Dicarboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and quantify impurities. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades, including research, development, and commercial scales, to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture. Due to its acidic nature, store away from strong bases, oxidizing agents, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.