Description

3,3'-Difluoro-4'-Methyl-[1,1'-Biphenyl]-4-Carboxylic Acid is a high-purity, functionalized biphenyl derivative serving as a critical advanced pharmaceutical intermediate (API) and versatile organic building block. Its molecular structure, featuring fluorine and carboxylic acid functional groups, makes it essential for synthesizing complex molecules with tailored properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and liquid crystal material industries.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Liquid Crystal Material Synthesis: Used as a core component in the production of fluorinated biphenyl-based liquid crystals for advanced display technologies (LCDs).
• Agrochemical Active Ingredient Precursor: Serves as a building block for novel herbicides, fungicides, and pesticides, leveraging the bioactivity imparted by the fluorine substituents.
• Organic Electronic Material Development: Employed in research for organic light-emitting diodes (OLEDs) and semiconductors due to its conjugated biphenyl system.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions to construct more complex biaryl systems.
• Ligand and Catalyst Design: The carboxylic acid group allows for derivatization into chelating ligands for metal-organic frameworks (MOFs) or asymmetric catalysis.

Basic Information

Product Name	3,3'-Difluoro-4'-Methyl-[1,1'-Biphenyl]-4-Carboxylic Acid
CAS No.	1261961-48-1
Molecular Formula	C14H10F2O2
Molecular Weight	248.23 g/mol
Synonyms	4'-Methyl-3,3'-difluorobiphenyl-4-carboxylic acid; 3,3'-Difluoro-4'-methylbiphenyl-4-carboxylic acid; [1,1'-Biphenyl]-4-carboxylic acid, 3,3'-difluoro-4'-methyl-; 4-(3-Fluoro-4-methylphenyl)-2-fluorobenzoic acid; 3-Fluoro-4'-(3-fluorophenyl)-4-methylbenzoic acid; Biphenyl-4-carboxylic acid, 3,3'-difluoro-4'-methyl- derivative
EINECS	Contact for details

Quality Control

Our 3,3'-Difluoro-4'-Methyl-[1,1'-Biphenyl]-4-Carboxylic Acid is manufactured under cGMP (current Good Manufacturing Practice) conditions to ensure the highest standards of purity and consistency for critical R&D and scale-up applications. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. Comprehensive Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.