Description

3-(4-Trifluoromethoxyphenyl)Isonicotinic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its distinct trifluoromethoxy-substituted aromatic structure. This compound is of significant commercial value for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high specificity and metabolic stability. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing next-generation small-molecule drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, especially for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials and liquid crystals due to its aromatic and fluorinated components.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	3-(4-Trifluoromethoxyphenyl)Isonicotinic Acid
CAS No.	1261783-07-6
Molecular Formula	C14H8F3NO3
Molecular Weight	295.22 g/mol
Synonyms	3-[4-(Trifluoromethoxy)phenyl]isonicotinic acid; 3-(4-Trifluoromethoxyphenyl)pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 3-[4-(trifluoromethoxy)phenyl]-; Isonicotinic acid, 3-(4-trifluoromethoxyphenyl)-; 1261783-07-6; 3-(p-Trifluoromethoxyphenyl)isonicotinic acid
EINECS	Contact for details

Quality Control

Our production of 3-(4-Trifluoromethoxyphenyl)Isonicotinic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity suitable for advanced synthetic applications. Each lot is analyzed using validated methods including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support development under cGMP guidelines and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.