Description

1-(2,4-Difluorophenyl)Cyclobutane-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a cyclobutane core substituted with a difluorophenyl moiety. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific stereochemistry and fluorinated components. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing next-generation small molecule drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially for CNS, anti-inflammatory, and antiviral applications.
• API Synthesis: Serves as a crucial precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Agrochemical Research: Used in the development of novel herbicides and pesticides, leveraging the biological activity of the fluorinated aromatic system.
• Chemical Biology Probes: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a scaffold for probe molecule design.
• Material Science: Potential monomer or additive for creating specialized polymers with unique thermal or chemical resistance properties.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical and agrochemical innovation pipelines.

Basic Information

Product Name	1-(2,4-Difluorophenyl)Cyclobutane-1-Carboxylic Acid
CAS No.	1260672-69-2
Molecular Formula	C11H10F2O2
Molecular Weight	212.19 g/mol
Synonyms	1-(2,4-Difluorophenyl)cyclobutanecarboxylic acid; Cyclobutanecarboxylic acid, 1-(2,4-difluorophenyl)-; 2,4-Difluoro-α-(cyclobutylidene)benzenemethanol (tautomeric form); 1-(2,4-Difluorophenyl)-1-cyclobutanecarboxylic Acid; Difluorophenyl cyclobutane carboxylic acid; 1260672-69-2; 1-(2,4-Difluorophenyl)cyclobutane carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(2,4-Difluorophenyl)Cyclobutane-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is compatible with strong acids and organic solvents but should be kept away from strong bases and oxidizing agents. Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.