Description

Abt-267 CAS NO 1258226-87-7 is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) research compound with significant pharmacological interest. This compound matters as a critical intermediate and reference standard in the development of novel antiviral therapeutics, particularly for HIV research. Pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in virology and medicinal chemistry are the primary users who need this material for their discovery and development programs.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of next-generation antiviral drug candidates.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in API manufacturing.
• Biochemical Assays: Employed in in vitro studies to investigate mechanisms of action, potency, and resistance profiles against HIV reverse transcriptase.
• Medicinal Chemistry: Provides a core scaffold for structure-activity relationship (SAR) studies and the design of novel NNRTI analogs.
• Preclinical Studies: Utilized in pharmacokinetic, pharmacodynamic, and toxicology profiling during early-stage drug discovery.

Basic Information

Product Name	Abt-267
CAS No.	1258226-87-7
Molecular Formula	C23H18F3N5O3S
Molecular Weight	501.48 g/mol
Synonyms	Doravirine (development code); MK-1439; 4-[[4-[[4-(2-Cyanoethenyl)-2,6-dimethylphenyl]amino]-5-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile; PNU-32945; Lersivirine analog; NNRTI inhibitor Abt-267; 1258226-87-7; Doravirine intermediate
EINECS	Contact for details

Quality Control

Our Abt-267 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and all relevant specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool, and well-ventilated place. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.