Description

Thiamine-[13C4] Hydrochloride is a stable isotope-labeled analog of Vitamin B1, where four carbon atoms are replaced with the 13C isotope. This compound is essential as an internal standard in quantitative mass spectrometry, providing unmatched accuracy for research and quality control in analytical chemistry. It is a critical tool for scientists and quality assurance professionals in pharmaceutical development, clinical research, nutritional analysis, and metabolomics studies.

Application

• Quantitative Mass Spectrometry (MS): Serves as a high-precision internal standard for the accurate quantification of native thiamine and its metabolites in complex biological matrices.
• Pharmaceutical R&D and Bioanalysis: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies to track drug metabolism and ensure accurate bioanalytical method validation.
• Clinical and Nutritional Research: Enables precise measurement of thiamine levels in blood, tissues, and food products for deficiency studies and nutritional labeling verification.
• Metabolomics and Stable Isotope Tracing: Facilitates flux analysis in metabolic pathway studies, allowing researchers to track the incorporation of labeled carbons.
• Quality Control & Reference Standard: Acts as a certified reference material (CRM) for calibrating instruments and validating analytical methods in quality control laboratories.
• Forensic and Doping Control Analysis: Provides definitive identification and quantification in forensic toxicology and anti-doping programs where precise measurement is legally critical.

Basic Information

Product Name	Thiamine-[13C4] Hydrochloride
CAS No.	1257525-77-1
Molecular Formula	C12[13C]4H18Cl2N4OS
Molecular Weight	Contact for details
Synonyms	Vitamin B1-[13C4] Hydrochloride; Thiamine Chloride-[13C4]; 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium Chloride-[13C4]; Aneurine-[13C4] Hydrochloride; Thiamin-[13C4] HCl; Stable Isotope Labeled Thiamine HCl; [13C4]-Thiamine Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Thiamine-[13C4] Hydrochloride is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to ensure product integrity, including confirmation of isotopic enrichment and chemical purity. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting results for assay, isotopic purity, and key impurities. Our quality commitment supports compliance with cGMP and ISO 17025 standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.