Description

n-(4-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Cyclopentanamine CAS NO 1256360-61-8 is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry. It is an essential building block for research and development chemists in the pharmaceutical and agrochemical industries, enabling the efficient construction of complex molecules for new drug candidates and active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between its aryl boronate group and various aryl/heteroaryl halides, facilitating the construction of biaryl and heterobiaryl scaffolds prevalent in modern drug molecules.
• Agrochemical Research & Development: Used in the discovery and synthesis of new herbicides, fungicides, and insecticides that require complex, fluorinated aromatic structures.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced organic electronic materials, such as OLEDs and organic semiconductors.
• Chemical Biology & Proteomics: Can be utilized as a tagging or labeling reagent for bioconjugation and the study of biological pathways.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Item	Details
Product Name	n-(4-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Cyclopentanamine
CAS No.	1256360-61-8
Molecular Formula	C18H27BFNO2
Molecular Weight	319.23 g/mol
Synonyms	N-[(4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]cyclopentanamine; 2-[(4-Fluoro-2-{[(cyclopentylamino)methyl]phenyl})]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Fluoro-2-(N-cyclopentylaminomethyl)phenylboronic acid pinacol ester; (4-Fluoro-2-((cyclopentylamino)methyl)phenyl)boronic acid pinacol ester; CAS 1256360-61-8; Cyclopentanamine, N-[(4-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]-; Boronic acid, B-[4-fluoro-2-[[(cyclopentylamino)methyl]phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all critical quality attributes. We support development and commercial projects requiring compliance with ICH guidelines and can tailor purity grades to meet specific project phases, from research to GMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain reactivity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.