Description

n-(4-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Propan-1-Amine is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern medicinal chemistry. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active compounds and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for compounds requiring a fluorinated aryl-boronate moiety.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aryl halides and boronic acids/esters, a cornerstone reaction in constructing complex biaryl structures.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that incorporate fluorinated aromatic systems for enhanced efficacy and stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of advanced organic electronic materials, such as OLEDs and organic semiconductors.
• Chemical Biology & Proteomics: Employed in the design and synthesis of chemical probes and bioconjugation reagents for target identification and protein labeling studies.

Basic Information

Product Name	n-(4-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Propan-1-Amine
CAS No.	1256360-59-4
Molecular Formula	C16H25BFNO2
Molecular Weight	293.19 g/mol
Synonyms	1-(4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)propan-1-amine; N-[2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-fluorobenzyl]propylamine; 4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylpropylamine; Propan-1-amine, N-[4-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]-; 1256360-59-4; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-fluorobenzylamine propyl derivative
EINECS	Contact for details

Quality Control

Our n-(4-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Propan-1-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.