Description

4-(2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Morpholine is a high-value, multifunctional boronic ester derivative that serves as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable building blocks for drug discovery and specialty chemical synthesis. CAS No. 1256360-51-6.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders, oncology, and inflammation.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides that leverage the morpholine and fluorinated aryl motifs for enhanced bioactivity and environmental stability.
• Material Science: Serves as a precursor for organic electronic materials, including monomers for conductive polymers and components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteomics: Employed in the development of molecular probes and activity-based protein profiling (ABPP) agents due to its reactive boronate handle.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to form biaryl and heterobiaryl bonds, a cornerstone of medicinal chemistry.
• Library Synthesis: A valuable reagent for high-throughput and combinatorial chemistry in drug discovery programs to rapidly generate diverse compound libraries.

Basic Information

Product Name	4-(2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Morpholine
CAS No.	1256360-51-6
Molecular Formula	C17H25BFNO3
Molecular Weight	321.20 g/mol
Synonyms	2-Fluoro-3-(morpholin-4-ylmethyl)phenylboronic acid pinacol ester; (2-Fluoro-3-((morpholin-4-yl)methyl)phenyl)boronic acid pinacol ester; 4-((2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl))morpholine; Morpholine, 4-[[2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]-; 3-((Morpholin-4-yl)methyl)-2-fluorophenylboronic acid pinacol ester; CAS 1256360-51-6; Pinacol (2-fluoro-3-(morpholinomethyl)phenyl)boronate
EINECS	Contact for details

Quality Control

Our 4-(2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Morpholine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural integrity suitable for sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.