Description

1-(2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Pyrrolidine is a high-value, synthetically versatile boronic ester derivative, serving as a critical building block in modern organic synthesis. Its core value lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures in a controlled manner. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity intermediates for drug discovery and specialty chemical production.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific fluorinated and boronate-containing scaffolds.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs and semiconductors, where the boronate group facilitates precise molecular assembly.
• Chemical Biology & Probe Development: Utilized as a building block for synthesizing molecular probes and bioconjugation reagents that target biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CMOs for client-specific projects requiring advanced boronic ester chemistry.
• Academic Research: A valuable reagent for methodology development and exploring new catalytic cycles in university and institutional laboratories.

Basic Information

Product Name	1-(2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Pyrrolidine
CAS No.	1256360-38-9
Molecular Formula	C17H25BFNO2
Molecular Weight	305.20 g/mol
Synonyms	2-Fluoro-3-((pyrrolidin-1-yl)methyl)phenylboronic acid pinacol ester; 1-[(2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]pyrrolidine; (2-Fluoro-3-((pyrrolidin-1-yl)methyl)phenyl)boronic acid pinacol ester; 3-((Pyrrolidin-1-yl)methyl)-2-fluorophenylboronic acid pinacol ester; CAS 1256360-38-9; Pinacol [2-fluoro-3-(pyrrolidin-1-ylmethyl)phenyl]boronate
EINECS	Contact for details

Quality Control

Our 1-(2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Pyrrolidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials undergo rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and mass spectrometry. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.