Description

2-(2-Chlorophenylmethoxy)-5-Fluorophenylboronic Acid is a specialized organoboron compound, a key building block in modern synthetic chemistry. Its value lies in its role as a versatile intermediate for constructing complex molecular architectures via cross-coupling reactions. This high-purity boronic acid is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A critical precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, enabling the creation of compounds with specific activity profiles.
• Material Science Research: Serves as a monomer or building block for creating organic electronic materials, such as those used in OLEDs and sensors.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-fidelity boronic acid reagents.
• Academic & R&D: Used in university and corporate research laboratories for methodological development and exploring new chemical spaces.

Basic Information

Product Name	2-(2-Chlorophenylmethoxy)-5-Fluorophenylboronic Acid
CAS No.	1256355-80-2
Molecular Formula	C13H11BClFO3
Molecular Weight	279.49 g/mol
Synonyms	[2-[(2-Chlorophenyl)methoxy]-5-fluorophenyl]boronic Acid; 5-Fluoro-2-[(2-chlorobenzyl)oxy]benzeneboronic Acid; 2-[(2-Chlorobenzyl)oxy]-5-fluorobenzeneboronic Acid; (5-Fluoro-2-{[(2-chlorophenyl)methyl]oxy}phenyl)boronic Acid; Boronic Acid, B-[2-[(2-chlorophenyl)methoxy]-5-fluorophenyl]-; 2-(2-Chlorobenzyloxy)-5-fluorophenylboronic Acid
EINECS	Contact for details

Quality Control

Our 2-(2-Chlorophenylmethoxy)-5-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive cross-coupling applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This material is light-sensitive and easily oxidized; prolonged exposure to air, light, or moisture should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.